Hypothesis: leukocyte endogenous mediator/endogenous pyrogen/lymphocyte-activating factor modulates the development of nonspecific and specific immunity and affects nutritional status.
نویسندگان
چکیده
We postulate that leukocyte endogenous mediator/endogenous pyrogen/lymphocyte-activating factor (LEM/EP/LAF) integrates the host's nonspecific and specific immune responses to infection by virtue of the panoply of physiological and metabolic activities it is capable of eliciting. The alterations in systemic metabolism modulated by LEM/EP/LAF, although apparently of value to the host in the defense against infection and the repair of tissue damage, result in negative nutrient balances. Severe infections, alone or in conjunction with injury, may result in malnutrition unless the patient is adequately nourished. Preexisting nutritional deficits can compromise host resistance to infection, in part by preventing production of LEM/EP/LAF. Additional studies of the sequelae of LEM/EP/LAF action and effects of nutrition on host resistance to infection appear warranted.
منابع مشابه
Studies on the mechanism of endogenous pyrogen production. II. Role of cell products in the regulation of pyrogen release from blood leukocytes.
Some characteristics of the process by which endogenous pyrogen (EP), the mediator of fever, is released from cells were examined by using human blood leukocytes incubated in vitro. Studies were designed to examine a possible role for leukocyte products, including EP, in the induction, augmentation, or suppression of pyrogen release by blood leukocytes. Products of stimulated leukocytes, includ...
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متن کاملMediators of Fever and Muscle
These new findings 2 extend the concept that activated PROTEOLYSIS phagocytic cells can produce hormone-like mediators to 0 signal distant tissues. Mediator activities are reflected by T IE accelerated catabolism of skeletal-muscle protein a variety of names,5 including "leukocytic pyrogen," "enthat accompanies severe trauma or infection can now be dogenous pyrogen," "leukocytic endogenous medi...
متن کاملMediators of Fever and Muscle
These new findings 2 extend the concept that activated PROTEOLYSIS phagocytic cells can produce hormone-like mediators to 0 signal distant tissues. Mediator activities are reflected by T IE accelerated catabolism of skeletal-muscle protein a variety of names,5 including "leukocytic pyrogen," "enthat accompanies severe trauma or infection can now be dogenous pyrogen," "leukocytic endogenous medi...
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عنوان ژورنال:
- The American journal of clinical nutrition
دوره 35 4 شماره
صفحات -
تاریخ انتشار 1982